Job Description

Associate Scientist Analytical Development - Early Development Job Description As an Associate Scientist working in the Analytical Development Early Development team, you will be empowered to lead technical activities and represent Analytical Development Early Development within departmental and cross‑functional teams. Position Objectives Support the transition of novel compounds (synthetic molecules, oligonucleotides, Protacs) from Discovery into Development, primarily through physicochemical profiling, pre‑clinical formulation research and biopharmaceutics. Interact with Discovery Teams, Drug Safety, DMPK, and collaborate closely with Process Chemistry, Formulation Development and Analytical Development to achieve project goals. Focus on salt/polymorph screening, solid state analytics and support preformulation/physicochemical profiling activities. Position Accountabilities Independently design, plan and execute studies on new development candidates to elucidate fundamental physicochemical properties and behaviors that enable lead candidate selection and downstream CMC development. Contribute to and drive solid state screening activities. Contribute to preformulation activities, physicochemical profiling and analytical method development. Support a cross‑functional Pharmaceutical Sciences team responsible for overseeing API salt and polymorph selection and subsequent development activities. Develop non‑GLP and GLP formulations based on the physical chemical properties of molecules and their route of delivery to support pre‑clinical studies. Conduct biorelevant in‑vitro studies to assess potential in‑vivo performance/impact of API and drug product changes during the development lifecycle. Provide significant technical leadership within a project and assist in strategy development across projects within the department or cross‑functionally. Interface with individual Pharmaceutical Science colleagues and cross‑functional project teams to ensure that development activities are consistent with the physicochemical properties of the API. Serve as a technical expert/SME for mentoring junior team members. Integrate scientific/technical efforts around cross‑functional issues. Plan and implement resolutions to technical problems/issues. Support local initiatives that may include technical or process‑related work streams. Author technical reports and contribute to regulatory filings. Education and Experience Bachelor’s degree in Pharmaceutics, Physical Organic Chemistry, Pharmacy, or related pharmaceutical science with 5+ years of relevant industry experience. Master’s degree in Pharmaceutics, Physical Organic Chemistry, Pharmacy, or related pharmaceutical science with 3+ years of relevant industry experience. Knowledge and Skills Strong understanding of polymorphism and solid state screening techniques. Strong understanding of solid state analytical techniques (XRPD/DSC/TGA/DVS). Skills in early formulation development and basic analytical method development (HPLC, GC). Analytical and problem‑solving skills—able to troubleshoot critical issues, determine causes, and implement solutions. Teamwork—ability to work well in highly cross‑functional team environments. Communication skills—able to express oneself clearly and concisely within teams; document issues and concerns effectively; technical writing skills for internal documents. Organization—excellent time management and prioritization; ability to juggle multiple tasks. Knowledge sharing—capture and disseminate organizational knowledge to improve solutions and processes. Resource management—manage time and external resources (vendors) to meet departmental and corporate goals. Technical expertise—strong knowledge of physicochemical and preclinical formulation theory; hands‑on experience with DSC, TGA, HPLC, XRPD, Raman, PAT tools, and proven ability to work in a lab setting. Experience with modalities outside traditional small molecules (oligonucleotides, Protacs) and in‑silico predictive tools is highly valued. Travel Requirements May require approximately 5–10% travel. Compensation Summary U.S. Base Salary Range: $99,500.00 – $156,420.00. The actual base salary offered may vary based on qualifications, experience, skills, education, certifications, and location. U.S. employees may be eligible for short‑term and long‑term incentives, medical, dental, vision, 401(k) plan with company match, disability coverage, life insurance, tuition reimbursement, paid volunteer time, holidays, well‑being benefits, sick time, and paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. #J-18808-Ljbffr BioSpace

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